Cor Vasa 2025, 67(4):505-509 | DOI: 10.33678/cor.2025.029

Controlling Nutritional Status Score is Linked to Cardiovascular Diseases

Lutfu Askina, Yahya Urkmezb, Okan Tanriverdic
a Department of Cardiology, Gaziantep Islamic Science and Technology University, Gaziantep, Turkey
b Department of Internal Medicine, Gaziantep City Hospital, Gaziantep, Turkey
c Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey

Higher Controlling Nutritional Status (CONUT) scores have been linked to cardiovascular diseases (CVDs) such as coronary artery disease, stroke, and heart failure. Poor nutrition may cause inflammation and oxidative stress, which can lead to CVDs. However, the CONUT score and CVDs are complicated and impacted by age, sex, and comorbidities. Thus, the CONUT score should be used as part of a thorough evaluation of a patient's nutritional status and CV risk, not for diagnosis or therapy.

Keywords: Cardiovascular disease, CONUT score, Heart failure

Received: December 27, 2024; Revised: February 17, 2025; Accepted: February 20, 2025; Prepublished online: June 2, 2012; Published: October 6, 2025  Show citation

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Askin L, Urkmez Y, Tanriverdi O. Controlling Nutritional Status Score is Linked to Cardiovascular Diseases. Cor Vasa. 2025;67(4):505-509. doi: 10.33678/cor.2025.029.
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    References

    1. Askin L, Tanriverdi O. Is the Atherogenic Index of Plasma (AIP) a Cardiovascular Disease Marker? Cor Vasa 2023;65:100-103. Go to original source...
    2. Naseer M, Forssell H, Fagerstrom C. Malnutrition functional ability and mortality among older people aged 60 years: A 7-year longitudinal study. Eur J Clin Nutr 2016;70:399-404. Go to original source... Go to PubMed...
    3. Zhang X, Pang L, Sharma SV, et al. Malnutrition and overall survival in older patients with cancer. Clin Nutr 2021;40:966-977. Go to original source...
    4. Li H, Cen K, Sun W, et al. Prognostic value of geriatric nutritional risk index in elderly patients with heart failure: A meta-analysis. Aging Clin Exp Res 2021;33:1477-1486. Go to original source...
    5. Li H, Zhou P, Zhao Y, et al. Prediction of all-cause mortality with malnutrition assessed by controlling nutritional status score in patients with heart failure: A systematic review and meta-analysis. Public Health Nutr 2022;25:1799-1806. Go to original source... Go to PubMed...
    6. Ignacio de Ulibarri J, Gonzalez-Madrono A, de Villar NG, et al. CONUT: A tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp 2005;20:38-45.
    7. Wang B, Liu J, Chen S, et al. Malnutrition affects cholesterol paradox in coronary artery disease: A 41,229 Chinese cohort study. Lipids Health Dis 2021;20:36. Go to original source...
    8. Raposeiras Roubin S, Abu Assi E, Cespon Fernandez M, et al. Prevalence and prognostic significance of malnutrition in patients with acute coronary syndrome. J Am Coll Cardiol 2020;76:828-840. Go to original source... Go to PubMed...
    9. Takahashi T, Watanabe T, Otaki Y, et al. Prognostic significance of the controlling nutritional (CONUT) score in patients with acute coronary syndrome. Heart Ves 2021;36:1109-1116. Go to original source... Go to PubMed...
    10. Chen SC, Yang YL, Wu CH, et al. Association between pre-operative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention. Nutrients 2020;12:1295. Go to original source...
    11. Chen L, Huang Z, Li W, et al. Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease. Int Urol Nephrol 2022;54:429-435. Go to original source...
    12. Wei X, Chen H, You Z, et al. Nutritional status and risk of contrast-associated acute kidney injury in elderly patients undergoing percutaneous coronary intervention. Clin Exp Nephrol 2021;25:953-962. Go to original source...
    13. Efe SC, Karagoz A, Dogan C, et al. Prognostic significance of malnutrition scores in elderly patients for the prediction of contrast-induced acute kidney injury. Int J Clin Pract 2021;75:e14274. Go to original source...
    14. Sze S, Pellicori P, Zhang J, et al. Agreement and classification performance of malnutrition tools in patients with chronic heart failure. Curr Dev Nutr 2020;4:nzaa071. Go to original source...
    15. Basta G, Chatzianagnostou K, Paradossi U, et al. The prognostic impact of objective nutritional indices in elderly patients with ST-elevation myocardial infarction undergoing primary coronary intervention. Int J Cardiol 2016;221:987-992. Go to original source... Go to PubMed...
    16. Kalyoncuoglu M, Katkat F, Biter HI, et al. Predicting one-year deaths and major adverse vascular events with the controlling nutritional status score in elderly patients with non-ST-elevated myocardial infarction undergoing percutaneous coronary intervention. J Clin Med 2021;10:2247. Go to original source...
    17. Seidu S, Kunutsor SK, Khunti K. Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants. Scand Cardiovasc J 2020;54:280-293. Go to original source... Go to PubMed...
    18. Bian C, Wu Y, Shi Y, et al. Predictive value of the relative lymphocyte count in coronary heart disease. Heart Ves 2010;25:469-473. Go to original source... Go to PubMed...
    19. Zhu Y, Lu JM, Yu ZB, et al. Intra-individual variability of total cholesterol is associated with cardiovascular disease mortality: A cohort study. Nutr Metab Cardiovasc Dis 2019;29:1205-1213. Go to original source...
    20. He GD, Liu XC, Liu L, et al. A nonlinear association of total cholesterol with all-cause and cause-specific mortality. Nutr Metab 2021;18:25. Go to original source...
    21. Sueta D, Hokimoto S, Sakamoto K, et al. Validation of the high mortality rate of Malnutrition-Inflammation-Atherosclerosis syndrome: Community-based observational study. Int J Cardiol 2017;230:97-102. Go to original source... Go to PubMed...
    22. Huang L, He R, Sun X, et al. Association of Controlling Nutritional Status Score With Adverse Outcomes in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis. Angiology 2023;74:149-158. Go to original source...
    23. Boyraz B, Ibisoglu E, Aslan B. The prognostic value of the nutritional prognostic index (NPI) and controlling nutritional status (CONUT) scoring systems in non-ST elevated myocardial infarction patients over 65 years of age. Aging Clin Exp Res 2022;34:555-562. Go to original source...
    24. Zengin A, Karataş MB, Çanga Y, et al. Prognostic performance of Controlling Nutritional Status score in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Anatol J Cardiol 2022;26:23-28. Go to original source...
    25. Jayanama K, Theou O, Blodgett JM, et al. Frailty, nutrition-related parameters, and mortality across the adult age spectrum. BMC Med 2018;16:188. Go to original source... Go to PubMed...
    26. Abu-Sawwa R, Dunbar SB, Quyyumi AA, Sattler E. Nutrition intervention in heart failure: should consumption of the DASH eating pattern be recommended to improve outcomes? Heart Fail Rev 2019;24:565-573. Go to original source...
    27. McKeag NA, McKinley MC, Harbinson MT, et al. Dietary micronutrient intake and micronutrient status in patients with chronic stable heart failure: an observational study. J Cardiovasc Nurs 2017;32:148-155. Go to original source... Go to PubMed...
    28. Nishikawa H, Goto M, Fukunishi S, et al. Cancer cachexia: its mechanism and clinical significance. Int J Mol Sci 2021;22:8491. Go to original source... Go to PubMed...
    29. Ma T, Huang X, Zheng H, et al. SFRP2 improves mitochondrial dynamics and mitochondrial biogenesis, oxidative stress, and apoptosis in diabetic cardiomyopathy. Oxid Med Cell Longev 2021;2021:9265016. Go to original source...
    30. Hu Y, Yang H, Zhou Y, et al. Prediction of all-cause mortality with malnutrition assessed by nutritional screening and assessment tools in patients with heart failure: a systematic review. Nutr Metab Cardiovasc Dis 2022;32:1361-1374. Go to original source... Go to PubMed...
    31. Ju C, Zhou J, Lee S, et al. Derivation of an electronic frailty index for predicting short-term mortality in heart failure: a machine learning approach. ESC Heart Fail 2021;8:2837-2845. Go to original source... Go to PubMed...
    32. Kawata T, Ikeda A, Masuda H, Komatsu S. Changes in prognostic nutritional index during hospitalization and outcomes in patients with acute heart failure. Heart Vessels 2022;37:61-68. Go to original source...
    33. Kojima I, Tanaka S, Otobe Y, et al. What is the optimal nutritional assessment tool for predicting decline in the activity of daily living among older patients with heart failure? Heart Vessels 2022;37:1356-1362. Go to original source... Go to PubMed...
    34. Chen Y, Yang H, Lan M, et al. The controlling nutritional status score and risk factors associated with malnutrition in patients with acute ischemic stroke. Front Neurol 2023;14:1067706. Go to original source...
    35. Naito H, Hosomi N, Nezu T, et al. Prognostic role of the controlling nutritional status score in acute ischemic stroke among stroke subtypes. J Neurol Sci 2020;416:116984. Go to original source...
    36. López Espuela F, Roncero-Martín R, Zamorano JDP, et al. Controlling Nutritional Status (CONUT) Score as a predictor of allcause mortality at three months in stroke patients. Biol Res Nurs 2019;21:564-570. Go to original source...
    37. Bardon LA, Corish CA, Lane M, et al. Ageing rate of older adults affects the factors associated with, and the determinants of malnutrition in the community: a systematic review and narrative synthesis. BMC Geriatr 2021;21:676. Go to original source...
    38. Sabbouh T, Torbey MT. Malnutrition in stroke patients: risk factors, assessment, and management. Neurocrit Care 2018;29:374-384. Go to original source...
    39. Crary MA, Humphrey JL, Carnaby-Mann G, et al. Dysphagia, nutrition, and hydration in ischemic stroke patients at admission and discharge from acute care. Dysphagia 2013;28:69-76. Go to original source...
    40. Allard JP, Keller H, Jeejeebhoy KN, et al. Decline in nutritional status is associated with prolonged length of stay in hospitalized patients admitted for 7 days or more: a prospective cohort study. Clin Nutr 2016;35:144-152. Go to original source... Go to PubMed...
    41. Maia I, Xará S, Vaz D, Shiang T, Amaral TF. Undernutrition risk at hospital admission and length of stay among pulmonology inpatients. Pulmonology 2018;24:330-336. Go to original source...
    42. Hoskin S, Chow V, Kritharides L, Ng Chawn AC. Incidence and impact of hypoalbuminaemia on outcomes following acute pulmonary embolism. Heart Lung Circ 2020;29:280-287. Go to original source...
    43. Leij-Halfwerk S, Verwijs MH, van Houdt S, et al. Prevalence of protein-energy malnutrition risk in European older adults in community, residential and hospital settings, according to 22 malnutrition screening tools validated for use in adults ≥65 years: a systematic review and meta-analysis. Maturitas 2019;126:80-89. Go to original source... Go to PubMed...
    44. Yildirim B, Karakaya Z, Acar E, et al. Controlling Nutritional Status Score Predicts In-Hospital Mortality in Acute Pulmonary Embolism. Med Princ Pract 2022;31:439-444. Go to original source... Go to PubMed...
    45. Hayiroğlu Mİ, Keskin M, Keskin T, et al. A novel independent survival predictor in pulmonary embolism: prognostic nutritional index. Clin Appl Thromb Hemost 2018;24:633-639.
    46. Kuzuya M, Izawa S, Enoki H, et al. Is serum albumin a good marker for malnutrition in the physically impaired elderly? Clin Nutr 2007;26:84-90. Go to original source... Go to PubMed...
    47. Aruğaslan E, Zengin A, Karataş MB, Akyüz Ş. Prognostic Significance of Controlling Nutritional Status Score (CONUT) in Patients Undergoing Pericardiocentesis. Acta Cardiol Sin 2022;38:84-90.
    48. Fan H, Huang Y, Zhang H, et al. Association of Four Nutritional Scores With All-Cause and Cardiovascular Mortality in the General Population. Front Nutr 2022;9:846659. Go to original source...
    49. Büber İ, Adali MK, Kaya D, Kiliç İD, Yilmaz S, Dursunoğlu D. The Relationship Between Mitral Annular Calcification and Controlling Nutritional Status Score. Braz J Cardiovasc Surg 2022;37:908-913. Go to original source...
    50. Shi HY, Zhu P, Zhang M, Wang AH. [Correlation Between Controlling Nutritional Status Scores and Amputation Risks in Patients with Diabetic Foot Ulcers]. Sichuan Da Xue Xue Bao Yi Xue Ban 2022;53:993-997.
    51. Kurmus Ferik O, Akbuga K, Tolunay H, et al. Poor Nutritional Status Is Associated with Arrhythmic Events on 24-Hour Holter Recording. Med Princ Pract 2022;31:368-375. Go to original source... Go to PubMed...
    52. Furui K, Morishima I, Morita Y, et al. Impact of Preoperative Nutritional Status on the Outcome of Catheter Ablation for Atrial Fibrillation. Circ J 2022;86:268-276. Go to original source... Go to PubMed...

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