Cor Vasa 2025, 67(6):745-749

(Liver steatosis as a risk of coronary heart disease)

Rudolf Poledne^a, Dita Pajuelo^b, Ivana Králová Lesná^{a, c}

^a Laboratoř pro výzkum aterosklerózy, Centrum experimentální medicíny, Institut klinické a experimentální medicíny, Praha, Česká republika

^b Pracoviště zobrazovacích metod, Institut klinické a experimentální medicíny, Praha, Česká republika

^c Klinika anesteziologie, resuscitace a intenzivní medicíny, 1. lékařská fakulta Univerzity Karlovy a Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha, Praha, Česká republika

The prevalence of steatosis in MASLD (metabolic dysfunction-associated steatotic disease) varies in different populations, up to 30%. Although steatosis might progress into steatohepatitis, cirrhosis and finally to the liver failure, it is not a necessary development very probably. Simple steatosis is a reversible status related to the total volume of ectopic fat in the body. Triglyceride (TG) accumulation in the liver is partly genetically determined, but it is also related to nutrition. High content of saturated fat in the hypercaloric diet leads to an increase in the content of fat droplets in the hepatocytes, whereas unsaturated fat has the opposite effect. Also, a high-carbohydrate diet leads to the accumulation of liver TG. The only method for analysis of TG content in the liver is magnetic resonance spectroscopy. Numerous epidemiological data documenting a high risk of MASLD for cardiovascular disease. With respect to the high prevalence of MASLD in the majority of the Western population, accumulation of TG in the liver represents a high risk of cardiovascular disease.

Keywords: Liver steatosis, Metabolism, Myocardial infarction

Received: October 14, 2025; Revised: October 14, 2025; Accepted: October 31, 2025; Prepublished online: June 2, 2012; Published: December 15, 2025  Show citation